Targeted Surface Expression of an Exogenous Antigen in Stably Transfected Babesia bovis

Targeted Surface Expression of an Exogenous Antigen in Stably Transfected Babesia bovis

Babesia bovis is a tick-borne intraerythocytic protozoan responsible for acute disease in cattle which can be controlled by vaccination with attenuated B. bovis strains. Emerging B. bovis transfection technologies may increase the usefulness of these live vaccines. One use of transfected B. bovis parasites may be as a vaccine delivery platform. Previous transfection methods for B. bovis were li...

Genotypic diversity of merozoite surface antigen 1 of Babesia bovis within an endemic population

Multiple genetically distinct strains of a pathogen circulate and compete for dominance within populations of animal reservoir hosts. Understanding the basis for genotypic strain structure is critical for predicting how pathogens respond to selective pressures and how shifts in pathogen population structure can lead to disease outbreaks. Evidence from related Apicomplexans such as Plasmodium, T...

Babesia bovis: the development of an expression oligonucleotide microarray.

The availability of a stage-specific Babesia bovis expression profile can facilitate the identification of candidate vaccine antigens. In addition, highly expressed genes during a particular developmental stage may suggest their relevance during that stage. In this study, we generated and validated a custom B. bovis high density oligonucleotide microarray that can be used to examine gene expres...

An outbreak of Babesia bovis infection in cattle and its control

Babesia bovis merozoite surface antigen-1. Immunization of cattle with recombinant

Babesia bovis merozoite surface antigen-1.